[Producer cells of human alpha and gamma interferons]

The cells responsible for production of human alpha and gamma interferons with proper inducers were studied using methods for fractionation of human blood mononuclear cells. The results indicated cooperation and mutual regulation by cells of interferon production. Monocytes were shown to play the leading role in the synthesis of acid-stable alpha interferon, whereas accessory cells were required for gamma interferon synthesis by T lymphocytes. Acid-labile alpha interferon was produced predominantly by B cells with accessory participation of T lymphocytes.