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Increased oxidative stress in children with post infectious Bronchiolitis Obliterans

J Mallol1, V Aguirre, V Espinosa

  • 1Department of Paediatric Respiratory Medicine, Hospital CRS El Pino, University of Santiago de Chile (USACH). jmallol@vtr.net

Allergologia Et Immunopathologia
|January 7, 2011
PubMed

Insights

Children with post-infectious bronchiolitis obliterans exhibit significantly elevated lung oxidative stress. This study reveals increased lipid and protein oxidation, highlighting a key factor in this pediatric lung disease.

Area of Science:

  • Pediatric Pulmonology
  • Oxidative Stress Research
  • Infectious Disease Complications

Background:

  • Oxidative stress is implicated in post-transplant bronchiolitis obliterans.
  • Adenovirus-induced lung infections are a common cause of bronchiolitis obliterans in developing nations.
  • The oxidative status in children with post-infectious bronchiolitis obliterans remains uncharacterized.

Purpose of the Study:

  • To quantify oxidant and antioxidant markers in children with post-infectious bronchiolitis obliterans.
  • To assess the correlation between oxidative stress markers and lung function.
  • To investigate the specific oxidative and antioxidant profile in this pediatric population.

Main Methods:

  • Bronchoalveolar lavage fluid was analyzed for 8-isoprostane, protein carbonyls, catalase, and glutathione peroxidase (GPx) in 21 children.
  • Lung function was evaluated using spirometry and plethysmography.
  • Oxidant/antioxidant levels were correlated with lung function parameters.

Main Results:

  • Markedly increased oxidative stress (lipid and protein oxidation) was observed in bronchoalveolar lavage fluid.
  • Lung function showed moderate-severe distal airway narrowing.
  • No significant correlation was found between oxidant/antioxidant levels and lung function, but a distinct pattern of increased 8-isoprostane, carbonyls, and GPx with normal catalase was noted.

Conclusions:

  • This study provides the first evidence of markedly increased lung oxidative stress in children suffering from post-infectious bronchiolitis obliterans.
  • The findings suggest a significant role for oxidative damage in the pathogenesis of this condition in children.
  • Further research into targeted antioxidant therapies may be warranted.
Abstract

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