Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and Imaging Abnormalities Associated With Inducible Ventricular Arrhythmias During Electrophysiologic Study in Patients With Cardiac Sarcoidosis and Mildly Impaired Left Ventricular Function.

Journal of the American Heart Association·2026
Same author

Right Atrial Mass as Manifestation of Sarcoidosis.

JACC. Case reports·2025
Same author

The Varying Histology of Hepatic Sarcoidosis and the Relation of Bile Duct Damage and Loss to the Presence of Portal Hypertension and Cirrhosis.

Gastro hep advances·2025
Same author

Specific locations of myocardial inflammation and fibrosis are associated with higher risk of events in cardiac sarcoidosis.

Heart rhythm·2024
Same author

Leveraging AI technology in sarcoidosis.

Current opinion in pulmonary medicine·2024
Same author

Corrigendum: Sex differences in the genetics of sarcoidosis across European and African ancestry populations.

Frontiers in medicine·2024

Related Experiment Video

Updated: Jun 5, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Recent advances in sarcoidosis.

Adam S Morgenthau1, Michael C Iannuzzi

  • 1Department of Medicine, Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. adam.morgenthau@mssm.edu

Chest
|January 7, 2011
PubMed
Summary
This summary is machine-generated.

Researchers explored the causes and diagnosis of sarcoidosis, a complex granulomatous disease. While no single cause was found, advances include identifying potential antigens and improved diagnostic techniques like endobronchial ultrasound.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Experiment Videos

Last Updated: Jun 5, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Genetics

Background:

  • Sarcoidosis is a systemic granulomatous disease with unknown causes and varied presentations.
  • Recent research has focused on identifying etiologic factors and understanding genetic predispositions.
  • Diagnostic criteria remain based on clinical, radiological, and pathological findings, often requiring a biopsy.

Purpose of the Study:

  • To review recent advances in understanding the etiology, diagnosis, and treatment of sarcoidosis.
  • To highlight key findings from studies like the ACCESS trial.
  • To discuss current diagnostic modalities and emerging therapeutic strategies.

Main Methods:

  • Review of the multicenter ACCESS (A Case Control Etiologic Study of Sarcoidosis) trial.
  • Analysis of genetic studies, including genome-wide scans and gene expression.
  • Evaluation of diagnostic advancements such as endobronchial ultrasound and PET scanning.
  • Assessment of treatment outcomes for refractory disease and pulmonary hypertension.

Main Results:

  • No single causative agent for sarcoidosis identified, but Mycobacterium tuberculosis catalase-peroxidase protein emerged as a potential antigen.
  • Genetic studies have identified candidate genes and clarified cytokine dysregulation.
  • Endobronchial ultrasound-guided transbronchial needle aspiration and PET scanning have improved diagnostic accuracy and localization of disease.
  • Tumor necrosis factor inhibitors show promise for refractory cases, but optimal treatment for sarcoidosis-associated pulmonary hypertension is still under investigation.

Conclusions:

  • Sarcoidosis etiology remains multifactorial, with ongoing research into genetic and environmental factors.
  • Diagnostic capabilities have advanced, improving the identification of noncaseating granulomas and active disease sites.
  • While new treatments like TNF inhibitors offer hope for refractory sarcoidosis, further research is needed for specific complications like pulmonary hypertension.