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Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation01:38

Inflammation

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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

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Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

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Published on: April 18, 2011

Systemic inflammation and fracture healing.

Okan Bastian1, Janesh Pillay, Jacqueline Alblas

  • 1Departments of Surgery, University Medical Center Utrecht, The Netherlands.

Journal of Leukocyte Biology
|January 7, 2011
PubMed
Summary

Leukocytes (white blood cells) are crucial for bone repair. Systemic inflammation can alter these cells, potentially impairing fracture healing after major trauma.

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Area of Science:

  • Immunology
  • Orthopedics
  • Regenerative Medicine

Background:

  • Leukocytes play a vital role in host defense and bone repair.
  • Fracture healing is initiated by an inflammatory response involving leukocytes.
  • Leukocytes in fracture hematomas produce growth factors regulating healing.

Purpose of the Study:

  • To review the role of leukocytes in fracture healing.
  • To investigate the impact of systemic inflammation on tissue leukocytes.
  • To hypothesize how altered leukocytes impair fracture healing post-trauma.

Main Methods:

  • Review of existing literature on leukocyte function in inflammation and bone healing.
  • Analysis of how systemic inflammation affects leukocyte populations and properties.
  • Discussion of potential mechanisms linking altered leukocytes to impaired fracture healing.

Main Results:

  • Systemic inflammation alters circulating leukocyte numbers and characteristics.
  • These alterations are hypothesized to persist in tissue-resident leukocytes.
  • Impaired fracture healing is a potential consequence of these leukocyte changes.

Conclusions:

  • Leukocyte function is critical for effective fracture healing.
  • Systemic inflammation poses a risk to fracture repair by altering leukocyte profiles.
  • Understanding these mechanisms is key for managing fracture healing after trauma.