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Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax.

Liangpeng Yang1, Naoe Kotomura, Yik-Khuan Ho

  • 1Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.

Journal of Virology
|January 7, 2011
PubMed
Summary

The Human T-lymphotropic virus type 1 (HTLV-1) trans-activator Tax induces cellular senescence, not proliferation, by upregulating p21 and p27. A small cell variant population bypasses this senescence.

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