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Subclinical hypothyroidism in eastern Nepal: a hospital based study
V Rohil1, A K Mishra, M K Shrewastawa
1Department of Clinical Biochemistry, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. vishir@rediffmail.com
Kathmandu University Medical Journal (KUMJ)
|January 7, 2011
Summary
Subclinical hypothyroidism, a condition with serious health risks, affects over 20% of suspected cases in Nepal. Routine screening is recommended for women aged 20-59.
Area of Science:
- Endocrinology
- Thyroid Disorders
- Public Health
Background:
- Subclinical hypothyroidism poses significant health risks and can progress to overt disease.
- Early identification and management are crucial for preventing serious complications.
Purpose of the Study:
- To determine the prevalence of subclinical hypothyroidism among individuals suspected of thyroid dysfunction.
- To identify demographic groups at higher risk in Nepal.
Main Methods:
- Retrospective cross-sectional study analyzing thyroid function tests (TSH, free T3, free T4) from 2007.
- Utilized ELISA-based assays for serum hormone estimations.
- Included 1714 patients attending a thyroid laboratory in Dharan, Nepal.
Main Results:
- Overall prevalence of subclinical hypothyroidism was 20.42% (350 out of 1714 cases).
- Females constituted the majority of cases (75.55%), with the highest prevalence in the 20-59 age group.
- Elevated TSH levels, indicative of hypothyroidism, were observed in 26.02% of all cases.
Conclusions:
- The prevalence of subclinical hypothyroidism in Nepal is significantly higher than global averages.
- Targeted screening of women aged 20-59 is recommended due to higher prevalence in this demographic.
- Sensitive TSH testing using ELISA is the preferred screening method.
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