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Updated: Jun 5, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study
Susan W Sarsam1, David R Nutt, Katja Strohfeldt
1School of Pharmacy, University of Reading, Whiteknights Campus, Reading, RG6 6AD, UK.
Abstract:
Due to the pivotal role played by human serum albumin (HSA) in the transport and cytotoxicity of titanocene complexes, a docking study has been performed on a selected set of titanocene complexes to aid in the current understanding of the potential mode of action of these titanocenes upon binding HSA. Analysis of the docking results has revealed potential binding at the known drug binding sites in HSA and has provided some explanation for the specificity and subsequent cytotoxicity of these titanocenes. Additionally, a new alternative binding site for these titanocenes has been postulated.
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