Acute levetiracetam overdose presented with mild adverse events

Overdose of levetiracetam may produce neurotoxicity.

We reported a patient with epilepsy who took an overdose of 63 grams of levetiracetam with mild adverse events. The patient presented mild blurred vision and mild ataxia that rapidly subsided within one day with supportive care. The laboratory tests showed mild leucopenia and mild thrombocytopenia that gradually returned to normal within 2 months.

The pharmacokinetics, tolerability and adaptation of levetiracetam might play a role in the mild adverse events of levetiracetam overdose in our patient.