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Related Experiment Video

Updated: Jun 5, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
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Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Current practices in determining amnionicity and chorionicity in multiple gestations.

Jennifer J Wan1, David Schrimmer, Véronique Taché

  • 1Department of Reproductive Medicine, University of California, San Diego, Medical Center, 200 W. Arbor Drive, San Diego, CA 92103, USA.

Prenatal Diagnosis
|January 7, 2011
PubMed
Summary

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Accurate diagnosis of amnionicity and chorionicity (A/C) in multifetal gestations is crucial. A tertiary care center achieved 94.8% accuracy, significantly outperforming referring physicians.

Area of Science:

  • Perinatology
  • Maternal-Fetal Medicine
  • Diagnostic Ultrasound

Background:

  • Accurate determination of amnionicity and chorionicity (A/C) is vital for managing multifetal gestations.
  • Existing diagnostic accuracy by referring physicians can be variable.
  • Histopathology serves as the gold standard for A/C diagnosis.

Purpose of the Study:

  • To compare the diagnostic accuracy of A/C by referring physicians and a tertiary care center against histopathology.
  • To identify discrepancies in A/C diagnoses in multifetal pregnancies.

Main Methods:

  • Retrospective analysis of 289 multifetal gestations.
  • Comparison of A/C diagnoses from referring physicians, a tertiary care center, and histopathology.
  • Evaluation of diagnostic accuracy based on gestational age and type of multifetal pregnancy.

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Main Results:

  • Only 43.6% of A/C diagnoses by referring physicians were accurate prior to tertiary care evaluation.
  • The tertiary care center achieved 94.8% overall accuracy in A/C diagnosis.
  • The tertiary care center demonstrated 100% accuracy for first-trimester twins and triplets.

Conclusions:

  • Early sonographic assessment of key findings can ensure accurate A/C diagnosis.
  • Tertiary care centers significantly outperform general referral providers in A/C diagnosis.
  • Enhancing diagnostic skills in the community or encouraging referral for ambiguous cases is recommended.