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Related Concept Videos

RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

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Related Experiment Videos

Structural alignment of RNA with complex pseudoknot structure.

Thomas K F Wong1, T W Lam, Wing-Kin Sung

  • 1Department of Computer Science, University of Hong Kong, Hong Kong.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|January 8, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces new algorithms to identify non-coding RNA (ncRNA) by accurately analyzing complex pseudoknot structures. These methods enhance the discovery of related ncRNA molecules across different species.

Related Experiment Videos

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Molecular Biology

Background:

  • Non-coding RNA (ncRNA) secondary structure is crucial for biological function.
  • Accurate ncRNA identification relies on sequence and structural similarity analysis.
  • Existing algorithms struggle with complex pseudoknot structures in ncRNAs.

Purpose of the Study:

  • To develop novel algorithms for handling complex pseudoknot structures in ncRNA analysis.
  • To improve the identification of de novo ncRNA molecules based on structural similarity.
  • To extend the capabilities of ncRNA alignment tools for complex structures.

Main Methods:

  • Development of algorithms specifically designed for simple non-standard and recursive pseudoknots.
  • Testing algorithms against comprehensive databases like Rfam and PseudoBase.
  • Evaluation of algorithm performance in identifying related ncRNA families.

Main Results:

  • Proposed algorithms successfully handle simple non-standard and recursive pseudoknots.
  • The developed methods cover all known ncRNAs in Rfam and PseudoBase.
  • Algorithms demonstrate utility in identifying homologous ncRNAs across species.

Conclusions:

  • The new algorithms significantly advance the analysis of ncRNA structures, particularly those with pseudoknots.
  • This work facilitates more accurate and comprehensive identification of ncRNA families.
  • The findings contribute to a better understanding of ncRNA diversity and function.