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Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions

Published on: September 10, 2021

Viral gastroenteritis in adults.

Alexander J Eckardt¹, Daniel C Baumgart

¹Deutsche Klinik für Diagnostik, Division of Gastroenterology and Hepatology, D-65191 Wiesbaden, Germany.

Recent Patents on Anti-Infective Drug Discovery

|January 8, 2011

Summary

Viral gastroenteritis is a global health issue affecting adults, often spread by asymptomatic carriers. This review details common viral causes, focusing on prevention and treatment strategies, especially for Norovirus.

Area of Science:

Virology
Public Health
Infectious Diseases

Background:

Viral gastroenteritis is a significant global health concern, primarily affecting young children but also causing symptomatic illness and asymptomatic shedding in adults.
Waning immunity and asymptomatic viral shedding in adults contribute to the continued spread of gastroenteritis.
Understanding the epidemiology, structure, pathogenesis, and clinical aspects of common adult viral gastroenteritis pathogens is crucial.

Purpose of the Study:

To review the most common causes of viral gastroenteritis in adults, including Caliciviridae (Norovirus), Astroviruses, Enteric Adenoviruses, and Rotaviruses.
To discuss the epidemiologic, structural, pathogenic, and clinical features of these viruses.
To explore current and future prevention and treatment options, with a focus on Norovirus and vaccine development.

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Main Methods:

Literature review of viral gastroenteritis in adults.
Analysis of epidemiologic, structural, pathogenic, and clinical data for common viral agents.
Examination of current and emerging prevention and treatment strategies, including antiviral agents and vaccines.

Main Results:

Noroviruses are a predominant cause of adult viral gastroenteritis, alongside astroviruses, enteric adenoviruses, and rotaviruses.
While specific antiviral inhibitors are limited, non-specific agents and potential Norovirus targets exist.
Vaccine development represents a key future strategy for prevention.

Conclusions:

Viral gastroenteritis remains a substantial public health challenge in adults, necessitating comprehensive understanding and control measures.
Current treatment focuses on supportive care and non-specific antivirals, with Norovirus being a primary target for future interventions.
Vaccines hold significant promise for the future prevention of adult viral gastroenteritis.