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Elimination of blood group antigens: hope and reality

Claude Bagnis1, Jacques Chiaroni, Pascal Bailly

  • 1Laboratoire Hématologie Moléculaire, Établissement Français du Sang Alpes Méditerranée, UMR 6578, Université de la Méditerranée, Marseille, France.

British Journal of Haematology
|January 8, 2011
PubMed

In transfusion medicine, three major issues, i.e. heterogeneity of human blood groups, dependence of blood supply on donation, and shortage of some phenotypes, oblige clinicians to juggle with available biological material to avoid or limit post-transfusion reactions. This 'fact of life' has given impetus to a 30-year-old quest to achieve interchangeability of blood products between donors and recipients by eliminating blood group antigens.

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