Related Experiment Video
Updated: Jun 5, 2026

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
Published on: August 21, 2017
[Gluttony and penance--laxatives and 'liver stones']
Jeanin van Hooft1, Ronald Oude Elferink, Jurgen Seppen
1Academisch Medisch Centrum, Afd. Maag-, Darm- en Leverziekten, Amsterdam, the Netherlands.
Abstract:
Gluttony is not only a mortal sin, it is also an important cause of medical problems. After sinning a penance must be paid and for this mortal sin the most obvious penance is laxation. Alternative medicine provides help: numerous types of laxative that claim to have positive effects on mental health, detoxification and aid in weight loss are to be found on the internet. The most surprising claim is that laxatives expel gall stones. These 'liver-cleansing' treatments result in the excretion of soft, stone-like structures in the faeces which may be seen by patients as being gall stones. Such 'liver stones' have been described in the literature and it is understood that they develop from the olive oil that is taken with the course of laxatives. That passing such stones is not associated with a reduction in gall stones is hardly surprising. Although laxation has been regarded as beneficial since ancient times, it is not effective in removing gall stones.
Related Concept Videos
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...
Cholecystitis
Drugs Affecting GI Tract Motility: Other Laxatives
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Accessory Organs
Pyloric Obstruction