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Updated: Jun 5, 2026
09:32
Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
Published on: January 20, 2023
[Prediction of fluid responsiveness by physiological variables]
Da-xing Yu1, Li Weng, Jin-Min Peng
1Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi
|January 8, 2011
Summary
Pulse pressure changes after fluid challenge effectively predict fluid responsiveness in patients. Heart rate and central venous pressure changes do not reliably indicate volume status.
Area of Science:
- Critical Care Medicine
- Hemodynamics
- Physiology
Context:
- Fluid resuscitation is crucial in managing critically ill patients.
- Predicting fluid responsiveness is essential for optimizing hemodynamic management.
- Current methods for predicting fluid responsiveness have limitations.
Purpose:
- To evaluate the clinical utility of blood pressure, heart rate, and central venous pressure changes in predicting fluid responsiveness.
- To identify specific hemodynamic parameters that reliably indicate volume status.
Summary:
- This retrospective analysis of 86 fluid challenges in 39 patients examined hemodynamic variables before and after fluid administration.
- Changes in systolic blood pressure (ΔSBP), diastolic blood pressure (ΔDBP), pulse pressure (ΔPP), and mean arterial pressure (ΔMAP) were significantly higher in responders.
- Logistic regression identified ΔPP as the sole independent predictor of fluid responsiveness (OR 1.100). ΔPP ≥ 5 mm Hg predicted responsiveness with 78.4% sensitivity and 75.7% specificity.
Impact:
- Pulse pressure variation is a valuable, non-invasive tool for predicting fluid responsiveness in critically ill patients.
- This finding can guide fluid management strategies, improving patient outcomes.
- Central venous pressure and heart rate are not reliable indicators of fluid responsiveness.
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