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Related Experiment Video

Updated: Jun 5, 2026

Animal Models of Depression - Chronic Despair Model (CDM)

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Published on: September 23, 2021

[Depressions: current concepts].

¹INSERM U 669, Faculté de Médecine Paris-Sud, Service de psychiatrie, CHU de Bicêtre, AP-HP, Le-Kremlin-Bicêtre, France. emmanuelle.corruble@bct.ap-hop-paris.fr

|January 8, 2011

Summary

This summary is machine-generated.

The discovery of second-generation antidepressants has advanced the understanding and treatment of major depressive disorders. New definitions for long-term outcomes like remission and recovery are now standard in clinical practice and research.

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Area of Science:

Psychiatry and Pharmacology
Neuroscience

Context:

Advances in antidepressant development since the 1980s have significantly impacted major depressive disorder (MDD) management.
The focus has shifted from acute episodes to a long-term perspective on MDD.
Improved understanding of MDD's chronic nature and treatment trajectories.

Purpose:

To outline the evolution of understanding major depressive disorders.
To highlight the importance of long-term outcome definitions in MDD.
To underscore the role of these definitions in current clinical practice and research.

Summary:

The advent of second-generation antidepressants has enhanced knowledge and practices concerning major depressive disorders.
Long-term approaches to MDD have emerged, defining relapses, recurrences, and outcomes such as remission, recovery, and residual symptoms.
These definitions are now integral to daily clinical practice and serve as phenotypic descriptions for physiopathologic studies.

Impact:

Standardized definitions facilitate consistent patient assessment and treatment monitoring in major depressive disorders.
The use of these definitions in research supports the development of more targeted and effective therapies for MDD.
Enhanced understanding of MDD outcomes promises future therapeutic innovations.