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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Videos

Osteoporosis and mortality.

Ariane Leboime1, Cyrille B Confavreux, Nadia Mehsen

  • 1Service de Rhumatologie B, Université Paris-Descartes, Hôpital Cochin, 27 rue du faubourg Saint-Jacques, Paris, France.

Joint Bone Spine
|January 8, 2011
PubMed
Summary
This summary is machine-generated.

Osteoporosis poses a significant public health risk due to fractures, which increase morbidity, costs, and mortality. Effective osteoporosis management may reduce the risk of death associated with these fractures.

Related Experiment Videos

Area of Science:

  • Public Health
  • Gerontology
  • Orthopedics

Background:

  • Osteoporosis is a major public health concern linked to fractures, causing significant morbidity and financial costs.
  • Emerging data reveal that osteoporotic fractures, particularly hip fractures, are associated with increased mortality.
  • Fracture prevention is now a global health priority, with initiatives like the World Health Organization's inclusion of fracture prevention.

Purpose of the Study:

  • To review current data on the association between osteoporotic fractures and mortality.
  • To highlight the impact of osteoporosis on public health and mortality rates.
  • To emphasize the importance of osteoporosis management in mitigating mortality risks.

Main Methods:

  • Literature review of recent publications and data.
  • Analysis of epidemiological data on osteoporotic fractures and mortality.
  • Synthesis of findings from studies focusing on overall osteoporotic fractures and hip fractures.

Main Results:

  • Osteoporotic fractures contribute to a substantial burden of morbidity and financial cost.
  • Certain osteoporotic fractures are linked to excess mortality, underscoring their severity.
  • Hip fractures represent the most severe complication, leading to disability, dependency, and increased death risk.

Conclusions:

  • Osteoporotic fractures represent a critical public health issue with significant mortality implications.
  • Optimal management of osteoporosis is crucial for potentially reducing the risk of death.
  • Further research and public health measures are needed to address the mortality associated with osteoporotic fractures.