A roundabout way to the niche.

Kateri Moore1

  • 1Department of Gene Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. kateri.moore@mssm.edu

Cell Stem Cell
|January 8, 2011
PubMed
Summary

Robo4 plays a key role in hematopoietic stem cell (HSC) engraftment and mobilization. It works with Cxcr4 to guide and secure stem cells within their niche.

Related Concept Videos

Ecological Niches02:02

Ecological Niches

All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.Multiple species cannot occupy the exact same niche within their habitat. If the niches of two or more species overlap to a large extent, the competitive exclusion principle dictates that one species will outcompete the other, forcing it to...
Ecological Niche01:12

Ecological Niche

Microorganisms occupy diverse habitats and perform essential ecological functions that are defined by their ecological niches. A microbial niche encompasses the organism’s mode of survival, including resource acquisition, reproduction, and interactions with other species in its environment. This concept is vital for understanding microbial community dynamics, biogeography, and ecosystem functionality.The fundamental niche of a microorganism includes the full spectrum of environmental...
Routes of Persuasion02:20

Routes of Persuasion

Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
Indirect Motor Pathways01:22

Indirect Motor Pathways

The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
Optimal Foraging00:48

Optimal Foraging

How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...