Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Parental Care

Parental Care

Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The role of the placenta in the initiation of spiral artery remodelling in an early pregnant chimpanzee uterus.

Placenta·2017

Same author

Emil Selenka on the embryonic membranes of the mouse and placentation in gibbons and orangutans.

Placenta·2015

Same author

Perinatal origin of endometriosis revisited.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2015

Same author

PP085. Angiotensin II type 1 receptor antibodies increase angiotensin II sensitivity in pregnant rats.

Pregnancy hypertension·2015

Same author

The perinatal origins of major reproductive disorders in the adolescent: Research avenues.

Placenta·2015

Same author

Hysteroscopic diagnosis and excision of myometrial cystic adenomyosis.

Gynecological surgery·2014

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero

Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero

Published on: September 8, 2023

Deep placentation.

R Pijnenborg¹, L Vercruysse, I Brosens

¹Department of Woman & Child, University Hospital Leuven, B-3000 Leuven, Belgium. Robert.Pijnenborg@uzleuven.be

Best Practice & Research. Clinical Obstetrics & Gynaecology

|January 8, 2011

Summary

This summary is machine-generated.

Deep placentation involves extravillous trophoblast invasion into the uterine spiral arteries. Proper vascular remodelling by trophoblast ensures adequate maternal blood flow, crucial for healthy pregnancy outcomes.

More Related Videos

Ex Vivo Perfusion of the Rodent Placenta

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Related Experiment Videos

Last Updated: Jun 5, 2026

Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero

Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero

Published on: September 8, 2023

Ex Vivo Perfusion of the Rodent Placenta

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Area of Science:

Reproductive biology
Human pregnancy physiology
Vascular remodeling

Background:

Deep placentation is essential for human pregnancy, requiring extravillous trophoblast invasion.
This invasion targets the decidua and myometrium, including spiral arteries.

Purpose of the Study:

To elucidate the mechanisms of deep placentation and vascular remodeling in human pregnancy.
To understand the role of trophoblast invasion in spiral artery modification.

Main Methods:

Histological examination of placental bed and myometrial spiral arteries.
Analysis of extravillous trophoblast invasion patterns.
Observation of vascular smooth muscle and matrix changes.

Main Results:

Extravillous trophoblast invades the decidua and myometrium, including endovascularly into spiral arteries.
Decidual vascular remodeling precedes trophoblast invasion, involving smooth muscle changes.
Trophoblast invasion further remodels spiral arteries, replacing smooth muscle with a fibrinoid matrix.

Conclusions:

Deep endovascular trophoblast invasion is critical for placental function.
Defective vascular remodeling during placentation is linked to pregnancy complications.