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Iron homeostasis in mother and child during placental malaria infection

Susanne Van Santen1, Quirijn de Mast, Adrian J F Luty

  • 1Department of General Internal Medicine, Radboud University, Nijmegen Medical Center, Nijmegen, The Netherlands. s.vansanten@aig.umcn.nl

The American Journal of Tropical Medicine and Hygiene
|January 8, 2011
PubMed

In malaria-endemic areas, iron deficiency and placental Plasmodium falciparum infection commonly coexist. In primigravidae and their newborns, hepcidin and other iron parameters were evaluated in groups and classified according to placental P. falciparum and maternal anemia status. Mothers had relatively high hepcidin levels considering their low iron status. In cord blood, levels of hepcidin, hemoglobin, and other iron parameters were also similar for groups. We conclude that maternal hepcidin is not significantly altered as a function of placental infection and/or anemia. Importantly, fetal hemoglobin and iron status were also unaffected, regardless of the presence of placental infection or maternal anemia.

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