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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Related Experiment Video

Updated: Jun 5, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

[Fetal microchimerism and autoimmune disease].

Osamu Samura1

  • 1Department of Obstetrics and Gynecology, NHO Kure Medical Center and Chugoku Cancer Center, Kure, Japan.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|January 8, 2011
PubMed
Summary

Microchimerism involves cell transfer between distinct individuals. Fetal microchimerism in mothers is linked to autoimmune diseases and may play a role in tissue repair.

Area of Science:

  • Reproductive immunology
  • Cellular biology

Context:

  • Microchimerism, the exchange of cells between mother and fetus, is a recognized aspect of pregnancy.
  • Fetal microchimerism is implicated in several autoimmune diseases affecting women.

Purpose:

  • To explore the connection between fetal microchimerism and autoimmune conditions in women.
  • To investigate the potential role of microchimeric cells in maternal tissue repair.

Summary:

  • Fetal microchimerism, defined as the presence of fetal cells in maternal circulation, is studied in relation to autoimmune diseases like systemic sclerosis and lupus.
  • Emerging research suggests microchimeric cells may aid maternal tissue injury response through differentiation.

Impact:

  • Understanding microchimerism can inform women's health strategies and disease prediction.

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

  • Further research may elucidate microchimerism's dual role in disease pathogenesis and healing.