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Updated: Jun 5, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Tetanus immunity in neonates in a developed country
Andrea-Romana Prusa1, Ursula Wiedermann, David C Kasper
1Department of Pediatrics and Adolescent Medicine, Division of Paediatric Neonatology, Intensive Care and Neuropaediatry, Medical University of Vienna, Vienna, Austria.
Objective:
In consideration of comprehensive and well-established vaccination programmes in industrialized countries, it is expected that immunity against tetanus among expectant mothers and their offspring is complete. Our study evaluated seroprotection against tetanus among newborns in Austria, who may gain passive immunity by transplacental transfer of maternal tetanus antibody.
Methods:
Cord blood samples from 99 deliveries were analyzed for antibody concentration against tetanus toxoid by standardized ELISA.
Results:
85/99 (85.8%) individuals presented with levels of tetanus immunity having a protective antibody concentration ≥0.1 IU/ml. 9/99 (9.1%) samples showed low seropositivity, while in 5/99 (5.1%) samples no tetanus antibodies could be detected. The median antibody concentration was 0.95 IU/ml.
Conclusions:
Our data provide evidence for a lack of adequate tetanus immunity in 14.2% of newborns delivered in an Austrian University Hospital. This investigation is emphasizing the importance of stringent regimens concerning prenatal vaccination care, even in countries with generalized immunization programs. If indicated, maternal immunization during pregnancy should be initiated for protection of newborns.
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