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Diagnostic performance of a modified biophysical profile for fetal acidemia in high-risk pregnancies
Kovit Compitak1, Orapin Pheungtavechok
1Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Objective:
To determine the diagnostic performance of NST, AFI and modified-BPP for screening fetal acidemia in high-risk pregnancies.
Design:
Diagnostic tests.
Setting:
Srinagarind (tertiary) Hospital, Faculty of Medicine, Khon Kaen University.
Material And Method:
Between April 2000 and August 2001, we included 185 high risk singleton pregnancies, GA > 37 weeks, with NST and AFI once a week until delivery. Immediately after delivery, the umbilical artery blood gases were evaluated. Fetal acidemia was defined as an umbilical artery pH < 7.15. An abnormal modified-BPP was identified when either the NST was non-reactive or the AFI was < or = 5 cm.
Results:
Thirteen high risk pregnancies were excluded because the last test was more than 7 days before delivery. Of the remaining 172 pregnancies, total fetal acidemia was identified in 19 cases. The incidence of fetal acidemia was 11.05% (95% CI 6.63-15.73). Among the 19 cases, eight had non-reactive NST and 11 had AFI < or = 5 cm but 14 with abnormal modified-BPP. The sensitivity of NST, AFI and modified-BPP was 42.11% (95% CI 34.73-49.48), 57.89% (95% CI 50.52-65.27), and 73.68%. (95% CI 67.10-80.27), respectively. The specificity, PPV, NPV, accuracy of NST, AFI and modified-BPP were high but not statistically different.
Conclusion:
The modified-BPP had a significantly higher sensitivity than NST or AFI alone in screening for fetal acidemia, so a modified-BPP should be used to screen for fetal acidemia in high-risk pregnancies.
