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Related Experiment Video

Updated: Jun 5, 2026

Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination
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Reducing the multiple pregnancy rate in ART.

Mark Bowman1

  • 1Royal Price Alfred Hospital, Australia.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|January 11, 2011
PubMed
Summary
This summary is machine-generated.

Single embryo transfer in IVF significantly reduces multiple pregnancies without compromising overall success rates. This approach ensures a higher chance of a healthy singleton pregnancy, improving outcomes for assisted conception.

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization (IVF)

Background:

  • Multiple pregnancies resulting from assisted conception pose significant risks to both fetus and mother.
  • Reducing the incidence of multiple gestation is a key goal in modern IVF protocols.

Purpose of the Study:

  • To evaluate the efficacy of single embryo transfer (SET) in reducing multiple pregnancies within IVF.
  • To compare ongoing pregnancy rates and multiple gestation rates between SET and double embryo transfer (DET).

Main Methods:

  • A randomized trial comparing SET (blastocyst) with DET (day 2/3 embryos).
  • Analysis of cumulative pregnancy rates from fresh and frozen-thawed embryo transfers.
  • Comparison of multiple pregnancy rates between SET and DET groups.

Main Results:

  • SET achieved equivalent ongoing pregnancy rates to DET.
  • SET significantly reduced twin rates to zero in the initial study.
  • Cumulative pregnancy rates were similar for SET and DET, but SET had a substantially lower multiple pregnancy rate (5% vs 28%).

Conclusions:

  • Single embryo transfer is a viable strategy to reduce multiple pregnancies in IVF.
  • Advances in blastocyst culture and cryopreservation support SET without compromising cumulative pregnancy rates.
  • SET offers a safer alternative for assisted conception, prioritizing singleton pregnancies.