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Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

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Related Experiment Video

Updated: Jun 5, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Preterm labour management--an evidence--update.

Wirawit Piyamongkol1

  • 1Department of Obstetrics and Gynaecology, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Road, Sripoom, Mueang, Chiang Mai 50200, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|January 11, 2011
PubMed
Summary
This summary is machine-generated.

Identifying preterm birth risk involves biologic markers. Tocolytic agents like calcium channel blockers offer effective, safer alternatives to beta-adrenergic agonists for short-term use, improving neonatal outcomes.

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Electromyometrial Imaging of Uterine Contractions in Pregnant Women
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Electromyometrial Imaging of Uterine Contractions in Pregnant Women

Published on: May 26, 2023

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Pharmacology

Background:

  • Preterm birth is a major cause of infant mortality and morbidity.
  • Biologic markers and ultrasound aid in identifying preterm birth risk.
  • Effective management of preterm labor aims to reduce neonatal complications.

Purpose of the Study:

  • To review the efficacy and safety of various tocolytic agents used in preterm labor management.
  • To evaluate the optimal use of tocolytics and corticosteroids in different gestational periods.

Main Methods:

  • Review of existing literature on tocolytic agents and corticosteroid treatment for preterm birth.
  • Comparison of efficacy and side effect profiles of different tocolytic classes.
  • Analysis of treatment guidelines based on gestational age.

Main Results:

  • Beta-adrenergic agonists, while common, have significant side effects.
  • Calcium channel blockers and oxytocin receptor antagonists show comparable efficacy with fewer adverse effects.
  • Tocolytic use is recommended for 24-48 hours between 28-34 weeks gestation for fetal lung maturation.
  • Maintenance tocolytic therapy and prolonged pregnancy after 34 weeks do not improve outcomes.
  • A single course of corticosteroids is beneficial for fetal lung maturity, but repeated courses may be harmful.

Conclusions:

  • Calcium channel blockers are a cost-effective and convenient tocolytic option.
  • Short-term tocolytic use and timely corticosteroid administration are key in managing preterm birth.
  • Avoidance of maintenance tocolysis and unnecessary corticosteroid retreatment is advised.