Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Absorbable rings for pediatric valvuloplasty. Preliminary study.

J C Chachques1, C Acar, C Latremouille

  • 1Department of Cardiovascular Surgery, Broussais Hospital, Paris, France.

Circulation
|November 1, 1990
PubMed
Summary

An absorbable prosthetic ring (APR) made of polydioxanone (PDS) was developed to prevent secondary valvular stenosis in children. This innovative ring promotes the growth of a biologic fibroelastic ring, allowing for natural atrioventricular annulus growth.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose distribution of the brain tissue associated with cognitive functions in high-grade glioma patients.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2020
Same author

Cylindroma spine metastasis: Long-term follow-up is required.

Neuro-Chirurgie·2019
Same author

Whole brain radiotherapy with concurrent temozolomide in multifocal and/or multicentric newly diagnosed glioblastoma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2019
Same author

Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses.

EBioMedicine·2019
Same author

The Cape Town Declaration on Access to Cardiac Surgery in the Developing World.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2018
Same author

Prehospital triage of septic patients at the SAMU regulation: Comparison of qSOFA, MRST, MEWS and PRESEP scores.

The American journal of emergency medicine·2017

Area of Science:

  • Biomaterials Science
  • Pediatric Cardiology
  • Surgical Innovation

Background:

  • Secondary valvular stenosis is a significant complication following annular ring implantation in pediatric valvular repair.
  • Existing prosthetic rings can impede natural growth and lead to adverse outcomes in children.

Purpose of the Study:

  • To develop and evaluate an absorbable prosthetic ring (APR) that promotes biologic tissue integration and allows for atrioventricular annulus growth in pediatric patients.
  • To assess the safety and efficacy of a polydioxanone (PDS)-based APR in preventing secondary valvular stenosis.

Main Methods:

  • Twelve biodegradable PDS APRs were implanted in immature goats across various cardiac positions (right atrial, tricuspid, mitral).
  • APRs were covered with a high-porosity polyester sheath to prevent embolic complications.

Related Experiment Videos

  • Histological and echocardiographic analyses were performed at 6 and 12 months post-implantation.

    • Main Results:

    • Histological studies at 12 months revealed PDS absorption and the formation of a new biologic fibroelastic ring with collagen, elastic fibers, and mitotic fibroblasts.
    • Echocardiography demonstrated that the APRs and integrated fibrotic tissue maintained normal systolic and diastolic valve function.
    • The study observed stable and elastic annuloplasty without secondary stenosis in growing animals.

    Conclusions:

    • The PDS-based absorbable prosthetic ring (APR) successfully integrates with native tissue, forming a dynamic biologic ring that supports valvular function and allows for cardiac growth.
    • This novel approach offers a promising solution to prevent secondary valvular stenosis in pediatric valvular repair.
    • Further clinical studies are warranted to investigate the efficacy of APRs in pediatric patients with valvular disease.