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Updated: Jun 5, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
cis-Apa: a practical linker for the microwave-assisted preparation of cyclic pseudopeptides via RCM cyclative
Alice Baron1, Pascal Verdié, Jean Martinez
1Institut des Biomolécules Max Mousseron, UMR CNRS, Université Montpellier, France.
Abstract:
A new linker cis-5-aminopent-3-enoic acid (cis-Apa) was prepared for the synthesis of cyclic pseudopeptides by cyclization-cleavage by using ring-closing methatesis (RCM). We developed a new synthetic pathway for the preparation of the cis-Apa linker that was tested in the cyclization-cleavage process of different RGD peptide sequences. Different macrocyclic peptidomimetics were prepared by using this integrated microwave-assisted method, showing that the readily available cis-Apa amino acid is well adapted as a linker in the cyclization-cleavage process.
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