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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Facial growth in patients with apert and crouzon syndromes compared to normal children

Jacobus H Reitsma1, Edwin M Ongkosuwito, Peter H Buschang

  • 1Department of Orthodontics, Academic Centre of Dentistry, Amsterdam, The Netherlands. j.reitsma@acta.nl

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|January 11, 2011
PubMed

Insights

Children with Apert and Crouzon syndromes exhibit distinct facial growth patterns compared to controls. Syndromic patients show worsened midfacial underdevelopment and mandibular rotation.

Area of Science:

  • Craniofacial development
  • Genetics
  • Orthodontics

Background:

  • Apert and Crouzon syndromes are rare genetic disorders affecting craniofacial development.
  • Understanding their specific growth patterns is crucial for timely intervention.

Purpose of the Study:

  • To evaluate and compare vertical and sagittal facial growth in children with Apert and Crouzon syndromes against a nonsyndromic control group.

Main Methods:

  • A case-control study involving 62 syndromic patients (Apert and Crouzon) and 482 controls.
  • Lateral cephalograms were analyzed for horizontal and vertical cephalometric measurements (SNA, SNB, ANB, NSMe, palatal plane angles, lower facial height ratio).

Main Results:

  • Syndromic groups showed no change in SNA angle during growth, with lower SNA in Apert syndrome. ANB angles were smaller in syndromic patients.
  • Vertical analysis revealed increased lower facial height ratios in syndromic groups. A counterclockwise rotation of the palatal plane was observed in syndromic patients.

Conclusions:

  • Significant differences in sagittal and vertical jaw relationships exist between Apert syndrome, Crouzon syndrome, and control subjects.
  • Syndromic patients experience aggravated midfacial hypoplasia and anterior mandibular rotation, impacting facial structure.
Abstract

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