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Troponin I degradation in serum of patients with acute ischemic stroke

Jesper K Jensen1, Jonas Hallén, Terje Lund

  • 1Department of Cardiology, Odense University Hospital, Denmark. jesperkjensen@dadlnet.dk

Scandinavian Journal of Clinical and Laboratory Investigation
|January 11, 2011
PubMed

Insights

Troponin I degradation occurs in patients with acute ischemic stroke, similar to acute myocardial infarction. Further research is needed to understand the clinical impact of these troponin fragments.

Area of Science:

  • Biochemistry
  • Cardiology
  • Neurology

Background:

  • Troponin is a key biomarker for acute coronary syndrome.
  • Troponin degradation post-release is known in acute coronary syndrome.
  • Troponin degradation in non-acute coronary syndrome states is not well understood.

Purpose of the Study:

  • To investigate troponin degradation in patients with acute ischemic stroke.
  • To compare troponin degradation patterns in ischemic stroke with those in myocardial infarction.

Main Methods:

  • Daily measurement of cardiac troponin I (cTnI) in 244 acute ischemic stroke patients over 5 days.
  • Western blot analysis of cTnI using anti-cTnI antibodies.
  • Comparison with serum cTnI concentrations and degradation patterns from myocardial infarction patients.

Main Results:

  • Elevated troponin levels detected in 10% of patients.
  • Both intact cTnI and up to seven degradation fragments were identified.
  • Degradation patterns were similar to those observed in myocardial infarction.

Conclusions:

  • Cardiac troponin I degradation patterns in acute ischemic stroke resemble those in acute myocardial infarction.
  • The biological and clinical significance of troponin degradation in ischemic stroke requires further investigation.
Abstract

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