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Related Experiment Videos

Doxapram infusion during halothane anaesthesia in ponies.

P M Taylor1

  • 1Animal Health Trust, Newmarket, Suffolk.

Equine Veterinary Journal
|September 1, 1990
PubMed
Summary

Doxapram infusion during halothane anesthesia in ponies improved ventilation by decreasing carbon dioxide and increasing pH. However, it lightened anesthesia, requiring increased anesthetic depth.

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Area of Science:

  • Veterinary Anesthesiology
  • Equine Pharmacology

Background:

  • Halothane anesthesia in ponies commonly causes respiratory depression.
  • Monitoring respiratory and cardiovascular parameters is crucial during equine anesthesia.

Purpose of the Study:

  • To evaluate the effects of doxapram on respiratory and cardiovascular parameters during halothane anesthesia in ponies.
  • To assess the impact of doxapram on anesthetic depth and recovery in ponies.

Main Methods:

  • Six ponies received halothane anesthesia for 2 hours, with doxapram infused during the second hour.
  • Control trials involved two ponies receiving dextrose instead of doxapram.
  • Arterial blood gases, blood pressure, pulse rate, and ECG were monitored.

Main Results:

  • Doxapram infusion decreased arterial carbon dioxide tension and increased pH.
  • Arterial blood pressure increased, with no significant changes in pulse rate or ECG.
  • Anesthesia lightened during doxapram infusion, necessitating higher anesthetic concentrations.

Conclusions:

  • Doxapram can improve ventilation during halothane anesthesia in ponies.
  • The respiratory stimulant effect may necessitate adjustments to anesthetic depth.
  • Doxapram did not appear to affect the recovery period from anesthesia.

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