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Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population

Hanane Khoury1, Isla Ogilvie, Antoine C El Khoury

  • 1BioMedCom Consultants inc,, 1405 TransCanada Highway, Suite 310, Montreal, Quebec H9P 2V9, Canada. hanane_khoury@biomedcom.org

BMC Infectious Diseases
|January 11, 2011
PubMed

Insights

Rotavirus gastroenteritis (RVGE) significantly impacts children under five in the Middle East and North Africa, causing high hospitalization and mortality rates. A broad-coverage rotavirus vaccine is crucial to reduce this disease burden.

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • Rotavirus gastroenteritis (RVGE) is a leading cause of severe diarrhea in children globally.
  • Estimating the RVGE burden in children under five is critical for public health interventions in the Middle East, North Africa, and Turkey.

Purpose of the Study:

  • To estimate the burden of rotavirus gastroenteritis (RVGE) in children under five years old across the Middle East, North Africa, and Turkey.
  • To analyze the epidemiological characteristics and economic impact of RVGE in the specified regions.

Main Methods:

  • A systematic literature search was performed for studies published between 1999 and 2009.
  • Data on RVGE epidemiology, burden, and rotavirus genotypes were extracted and compared across countries.

Main Results:

  • 43 studies were identified, showing RVGE prevalence in 16-61% of acute gastroenteritis cases, peaking in winter.
  • RVGE-related hospitalizations ranged from 14% to 45%, with annual fatalities up to 112 per 100,000 in some areas.
  • Significant economic burden was noted, with hospitalization costs between $1.8-$4.6 million annually; G1P[8] and G2P[4] were prevalent genotypes.

Conclusions:

  • RVGE poses a substantial morbidity, mortality, and economic challenge in the studied regions.
  • The diversity of rotavirus strains necessitates a vaccine with broad and consistent serotype coverage.
  • Vaccination strategies are essential to mitigate the RVGE burden in the Middle East and North Africa.
Abstract

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