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[Association between diastolic dysfunction evaluated by left ventricular flow propagation velocity and outcome in

Di Wu1, Jun Xue, Yan-Qiu Zhou

  • 1Heart Center, Mei-tan General Hospital, Beijing 100028, China. wudimd07@sohu.com

Zhonghua Xin Xue Guan Bing Za Zhi
|January 11, 2011
PubMed

Insights

Left ventricular diastolic dysfunction in hypertrophic cardiomyopathy (HCM) is linked to adverse events. Lower flow propagation velocity (FPV) and FPV/E ratio predict clinical outcomes, including heart failure and atrial fibrillation.

Area of Science:

  • Cardiology
  • Echocardiography
  • Diastolic Function

Background:

  • Left ventricular diastolic dysfunction is prevalent in cardiovascular diseases, notably hypertrophic cardiomyopathy (HCM).
  • Flow propagation velocity (FPV), measured by color M-mode Doppler, serves as an indicator of diastolic dysfunction.

Purpose of the Study:

  • To investigate the association between left ventricular flow propagation velocity (FPV) and clinical outcomes in patients with HCM.
  • To determine if FPV can predict adverse cardiovascular events in HCM patients.

Main Methods:

  • Standard echocardiography, including FPV assessment, was performed on 43 HCM patients and 22 controls.
  • Follow-up exceeded 1 year to monitor clinical events.

Main Results:

  • HCM patients exhibited significantly lower FPV and FPV/E ratios compared to controls (P < 0.01).
  • Hospitalization rates for atrial fibrillation/flutter, ventricular tachycardia, and heart failure were 21%, 16%, and 26%, respectively.
  • FPV/E independently predicted atrial fibrillation/flutter and heart failure; LAD and FPV/E were independent risk factors for total cardiac events.

Conclusions:

  • Left ventricular diastolic dysfunction, indicated by reduced FPV/E, is closely related to atrial fibrillation and heart failure in HCM.
  • FPV/E is an independent predictor of clinical cardiovascular events in patients with HCM.
Abstract

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