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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Assessing Body Temperature - Tympanic membrane01:14

Assessing Body Temperature - Tympanic membrane

Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
Assessing Body Temperature - Rectal01:27

Assessing Body Temperature - Rectal

Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
Step 3: Assess the patient's forehead...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Assessing Body Temperature - Oral01:14

Assessing Body Temperature - Oral

Here are the steps to accurately measure oral temperature using an electronic thermometer:
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...

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Related Experiment Video

Updated: Jun 5, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPV1 as a cough sensor and its temperature-sensitive properties.

Lu-Yuan Lee1, Dan Ni, Don Hayes

  • 1Department of Physiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USA. lylee@uky.edu

Pulmonary Pharmacology & Therapeutics
|January 11, 2011
PubMed
Summary

Transient Receptor Potential Vanilloid 1 (TRPV1) channels in airway nerves significantly influence cough and bronchoconstriction. Temperature and inflammatory mediators modulate TRPV1, impacting respiratory reflexes.

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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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Last Updated: Jun 5, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Published on: December 31, 2013

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08:35

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Published on: March 17, 2015

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

Area of Science:

  • Neuroscience
  • Respiratory Physiology
  • Molecular Biology

Background:

  • Transient Receptor Potential Vanilloid 1 (TRPV1) channels are expressed in airway sensory nerves.
  • TRPV1 plays a key role in initiating the cough reflex.
  • Inflammatory mediators and temperature can modulate TRPV1 activity.

Purpose of the Study:

  • To investigate the role of TRPV1 in airway sensory nerve function.
  • To explore the influence of temperature on TRPV1-mediated airway reflexes.
  • To understand TRPV1's contribution to conditions like chronic cough.

Main Methods:

  • Inhalation of capsaicin aerosol in humans and animal models.
  • Measurement of cough reflex sensitivity.
  • Immunohistochemical analysis of TRPV1 in bronchial tissues.
  • Electrophysiological recordings of vagal pulmonary sensory neurons.

Main Results:

  • Capsaicin inhalation dose-dependently evoked coughs in healthy individuals and patients.
  • Inflammatory mediators (prostaglandin E2, bradykinin) enhanced cough sensitivity.
  • Increased TRPV1 nerve profiles were observed in chronic cough patients' bronchial tissue.
  • Elevated temperature increased activity and sensitivity of rat vagal pulmonary sensory neurons via TRPV1.

Conclusions:

  • TRPV1 activation is critical for cough reflex and airway sensory nerve responses.
  • TRPV1 sensitivity is modulated by inflammatory mediators and temperature.
  • TRPV1's temperature sensitivity may regulate airway sensory nerve function and reflex sensitivity.