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Updated: Jun 5, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Antibiotic multiresistance in critical care units]

M J López-Pueyo1, F Barcenilla-Gaite, R Amaya-Villar

  • 1Servicio de Medicina Intensiva, Complejo asistencial de Burgos, Burgos, España. mjlp@hgy.es

Medicina Intensiva
|January 11, 2011
PubMed

Insights

Managing critically ill patients with multidrug-resistant organisms requires intensivists to control transmission and select appropriate antibiotic treatments. This review covers resistance, control measures, and treatment strategies, including national data.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Multidrug-resistant organisms (MDROs) pose significant challenges in intensive care units (ICUs).
  • Intensivists play a crucial role in preventing and controlling MDROs and managing infections.
  • Effective antibiotic stewardship is vital for patient outcomes.

Purpose of the Study:

  • To review the literature on multidrug resistance in critically ill patients.
  • To discuss transmission, control measures, and treatment options for MDRO infections.
  • To present national data on multidrug resistance in ICUs.

Main Methods:

  • Comprehensive literature review on multidrug resistance.
  • Analysis of transmission dynamics and control strategies.
  • Inclusion of national surveillance data (ENVIN-UCI register).

Main Results:

  • Multidrug resistance complicates patient management and outcomes in critical care.
  • Effective control requires a multi-faceted approach, including infection prevention and appropriate treatment.
  • National data highlights the prevalence and impact of MDROs.

Conclusions:

  • Addressing multidrug resistance necessitates specialized training for intensivists.
  • Teamwork with other specialists and local environmental adaptation are essential.
  • Proactive strategies are crucial for combating MDROs in ICUs.

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