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A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Vascular access for hemodialysis in the elderly
Nicola Swindlehurst1, Andrew Swindlehurst, Heather Lumgair
1Department of Transplant Surgery, Guy’s and St Thomas’ NHS Foundation Trust, United Kingdom. nicola.swindlehurst@doctors.org.uk
Insights
Vascular access creation for hemodialysis in elderly patients (≥65 years) shows comparable outcomes to younger patients (<65 years). Arteriovenous fistulas in the elderly demonstrate high patency rates and shorter hospital stays, making them a viable option.
Area of Science:
- Vascular Surgery
- Nephrology
- Geriatric Medicine
Background:
- Increasing prevalence of elderly patients requiring hemodialysis.
- Challenges in creating effective vascular access for hemodialysis in older adults.
- Need to evaluate outcomes of hemodialysis access in elderly populations.
Purpose of the Study:
- To analyze the outcomes of conduit creation for hemodialysis in elderly patients (≥65 years).
- To compare the outcomes of vascular access in elderly patients with a younger cohort (<65 years).
Main Methods:
- Retrospective analysis of prospectively collected data from January 1, 2000, to December 31, 2006.
- Inclusion of first-time arteriovenous fistula (AVF) and graft creations.
- Comparison between elderly (Group A, ≥65 years) and non-elderly (Group B, <65 years) patients.
Main Results:
- No significant differences in primary patency (70% vs 68%), assisted primary patency (73% vs 77%), or secondary patency (73% vs 79%) between groups.
- Higher incidence of failure to mature in the elderly group (6.1% vs 1.1%, P = .03).
- Similar rates of death with functioning conduit (56% vs 54%) and mean conduit survival.
- Lower rate of salvage procedures in the elderly group (2.5% vs 10.1%).
- Shorter mean hospital stay for elderly patients (3.2 days).
Conclusions:
- Creation of permanent hemodialysis access, particularly arteriovenous fistulas, is feasible and effective in elderly patients.
- Elderly patients experience high patency rates and acceptable intervention rates for hemodialysis access.
- Short hospital stays are associated with hemodialysis access creation in the elderly.
Objective:
The number of elderly patients needing hemodialysis is constantly increasing year by year. Elderly patients with end-stage renal failure represent a challenge for the surgeons who create vascular accesses. The aim of this study was to analyze the outcome of conduit creation in the elderly in our institution and to compare it with the outcome of a cohort of patients aged <65 years.
Methods:
The study was performed retrospectively on prospectively collected data. The study period was between January 1, 2000, and December 31, 2006. We identified first attempts at conduit creations, including arteriovenous fistulas (AVFs) and grafts, in elderly patients (aged ≥65 years) who were allocated to group A, and in nonelderly patients (<65 years) who were allocated to group B. Subsequent attempts at conduit creations in the same patient were omitted from the data set.
Results:
There were 246 first AVFs in group A and 89 in group B. At a mean follow-up of 25.46 months (SD, 18.93 months), the primary patency (PP) rate of all AVFs was 70% in group A and 68% in group B (P = .75). The assisted PP rate was 73% in group A and 77% in group B (P = .4). The secondary patency (SP) rate was 73% in group A and 79% in group B (P = .9). Also, the differences in the 12-month cumulative patency rates (including PP, assisted PP, and SP) in the two groups (65% vs 60%) were not significant. At a mean follow-up of 25 months, death with a functioning conduit occurred at the same rate in both groups (56% and 54%), and mean conduit survival did not differ according to age (516 and 511 days). The incidence of failure to mature was higher in group A (6.1% vs 1.1%, P = .03). Patency rates for different types of conduits were similar between the two groups, although polytetrafluoroethylene grafts had a higher cumulative patency in group A (94% vs 69%; P = .05). The rate of procedures to salvage conduits was 2.5% in group A vs 10.1% in group B. Mean hospital stay for group A and group B was 3.2 days.
Conclusions:
In our experience, the creation of permanent hemodialysis access in the elderly with AVF is not only possible but also proved to have a short hospital stay, high patency rates, and an acceptable rate of further intervention.
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