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A novel replicated association between FXYD6 gene and schizophrenia
Nannan Zhong1, Rui Zhang, Chuan Qiu
1Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, PR China.
Biochemical and Biophysical Research Communications
|January 11, 2011
Summary
This study investigated the FXYD6 gene
Area of Science:
- Genetics
- Neuroscience
- Psychiatry
Background:
- The FXYD6 gene, located in chromosome region 11q22-q24, has been previously associated with schizophrenia.
- Replication studies have yielded inconsistent findings regarding this association.
Purpose of the Study:
- To investigate the association between the FXYD6 locus and schizophrenia in the Han Chinese population.
- To identify specific single-nucleotide polymorphisms (SNPs) and haplotypes within FXYD6 linked to schizophrenia risk.
Main Methods:
- Genotyping of six single-nucleotide polymorphisms (SNPs) in the FXYD6 gene.
- Association analysis performed on 1142 Han Chinese individuals (576 cases, 566 controls).
Main Results:
- Significant association found between schizophrenia and the FXYD6 marker rs11544201 (P=0.0028).
- A significant association was also observed for the haplotype rs10790212-rs11544201 (global P=0.005).
Conclusions:
- The findings support FXYD6 as a potential susceptibility gene for schizophrenia in the Chinese population.
- Further research with larger sample sizes and functional analyses of FXYD6 is warranted.
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