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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Cardiac dysfunction in juvenile dermatomyositis: a case-control study.

Thomas Schwartz1, Helga Sanner, Trygve Husebye

  • 1Institute for Experimental Medical Research, Oslo University Hospital, 0407 Oslo, Norway. thomas.schwartz@medisin.uio.no

Annals of the Rheumatic Diseases
|January 11, 2011
PubMed
Summary
This summary is machine-generated.

Patients with juvenile dermatomyositis (JDM) exhibit subclinical heart disease, including diastolic dysfunction and hypertension, unlike healthy controls. Early disease activity predicts long-term cardiac abnormalities in JDM patients.

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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Area of Science:

  • Cardiology
  • Rheumatology
  • Pediatric Medicine

Background:

  • Juvenile dermatomyositis (JDM) is a systemic autoimmune disease affecting children.
  • Cardiac involvement in JDM is not fully understood, necessitating investigation into cardiac function.
  • Subclinical cardiac abnormalities may impact long-term outcomes in JDM patients.

Purpose of the Study:

  • To compare cardiac function in JDM patients with age- and sex-matched controls.
  • To identify associations between electrocardiography (ECG) and echocardiographic findings and disease variables in JDM.
  • To investigate subclinical left ventricular diastolic dysfunction in JDM.

Main Methods:

  • A cohort of 59 JDM patients and 59 controls underwent echocardiography and 12-channel ECG.
  • Echocardiography assessed diastolic function using early diastolic transmitral flow/early diastolic tissue velocity (E/E').
  • Disease activity and damage were evaluated through clinical assessment and chart review.

Main Results:

  • Elevated E/E' (diastolic dysfunction) was observed in 22% of JDM patients versus 0% of controls (p<0.001).
  • JDM patients showed a higher prevalence of pathological ECG (p=0.054) and hypertension (p<0.001).
  • Elevated E/E' correlated with cumulative organ damage (r(sp)=0.41, p=0.001) and early disease activity (r(sp)=0.56, p<0.001).

Conclusions:

  • Subclinical left ventricular diastolic dysfunction is present in JDM patients, associated with pathological ECG and hypertension.
  • High disease activity at one year post-diagnosis predicts diastolic dysfunction at follow-up.
  • These findings highlight the systemic nature of JDM and its impact on cardiac health.