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Related Concept Videos

Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...

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Related Experiment Video

Updated: Jun 5, 2026

RNA Isolation from Mouse Ocular Lens Epithelium and Fiber Cell Bulk Masses
06:07

RNA Isolation from Mouse Ocular Lens Epithelium and Fiber Cell Bulk Masses

Published on: October 10, 2025

Cadm1 expression and function in the mouse lens.

Alicia De Maria1, Yanrong Shi, Xianmin Luo

  • 1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.

Investigative Ophthalmology & Visual Science
|January 11, 2011
PubMed
Summary

Cell adhesion molecule Cadm1 is crucial for maintaining lens fiber cell structure, despite not affecting lens transparency. Its absence leads to irregular cell morphology in the lens.

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Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization
05:45

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization

Published on: January 19, 2024

Area of Science:

  • Cell Biology
  • Ophthalmology
  • Molecular Biology

Background:

  • Cadm1 (Cell adhesion molecule 1) is a type 1 membrane protein involved in cell-cell adhesion.
  • Cadm1 has roles in tumor formation and synaptogenesis.
  • Cadm1 is a major protein in mouse lens cell membranes.

Purpose of the Study:

  • To investigate the expression and function of Cadm1 in the mouse lens.
  • To determine Cadm1's role in lens cell architecture and transparency.

Main Methods:

  • Western blotting and immunofluorescence were used to analyze Cadm1 expression.
  • Confocal microscopy visualized the morphology of wild-type and Cadm1-null lens cells.

Main Results:

  • Cadm1 is a heavily glycosylated protein found in lens epithelial and superficial fiber cells.
  • Cadm1 is degraded during fiber cell differentiation, similar to lens organelles.
  • Cadm1-null mice lenses were transparent, but fiber cells exhibited irregular morphology.

Conclusions:

  • Cadm1 is abundant in the lens fiber cell membrane.
  • Cadm1 is essential for the three-dimensional architecture of the lens fiber cell mass.
  • Cadm1 is not essential for maintaining lens transparency.