Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 5, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Dual and single memory rod construct comparison in an animal study.

Peter O Newton1, Christine L Farnsworth, Vidyadhar V Upasani

  • 1Rady Children's Hospital, and University of California, San Diego, San Diego, CA 92123, USA. pnewton@rchsd.org

Spine
|January 11, 2011
PubMed
Summary

Nitinol rods effectively created spinal deformities in mini-pigs, showing potential for future clinical use in spinal deformity correction. Locked rods demonstrated better correction, though vertebral fractures occurred.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pseudoarthrosis After Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis: A Multicenter Analysis of Revision Strategies and Outcomes.

Spine·2026
Same author

Effectiveness of suspension bending cast for early-onset scoliosis.

Spine deformity·2026
Same author

Prospective Vertebral Body Tethering Data: Commentary on an article by A. Noelle Larson, MD, et al.: "Vertebral Body Tethering in Skeletally Immature Patients. Results of a Prospective U.S. FDA Investigational Device Exemption Study".

The Journal of bone and joint surgery. American volume·2026
Same author

Transverse-plane descriptors and modifiers of the SRS-Lenke-Aubin 3D classification provide complementary and clinically informative 3D features beyond 2D assessment in Lenke 1 AIS curves.

Spine deformity·2026
Same author

Distribution of curve flexibility in AIS: a multicenter study of 5,267 patients.

Spine deformity·2026
Same author

Correction: The SRS-Lenke-Aubin 3D classification of adolescent idiopathic scoliosis.

Spine deformity·2026

Area of Science:

  • Spinal Surgery
  • Biomaterials Science
  • Orthopedic Research

Background:

  • Nitinol (nickel-titanium) shape memory alloy rods offer theoretical advantages for spinal deformity correction due to their ability to be deformed and return to their original shape.
  • Square cross-section nitinol rods may enable correction in the transverse plane, while single-rod constructs might offer greater correction but dual rods provide enhanced stability.
  • This study investigated the clinical feasibility and effectiveness of single versus dual nitinol rod constructs in an animal model for spinal deformity creation.

Purpose of the Study:

  • To evaluate the practicality of using nitinol rods for clinical spinal deformity correction.
  • To assess the effectiveness of single versus dual nitinol rod constructs in creating spinal deformity.
  • To compare locked versus unlocked screw-rod constructs in an animal model.

More Related Videos

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Main Methods:

  • Single or dual square nitinol rods with 80° manufactured curvature were used in a mini-pig model.
  • Rods were cooled to -20°C, straightened, placed into pedicle screws, and warmed to 40°C to induce deformity.
  • Serial radiographs and CT scans were used to assess deformity, screw placement, and fusion over 12 weeks. Serum nickel levels were also monitored.

Main Results:

  • Immediate scoliotic deformities were successfully created in all groups, with no significant difference between single/dual or locked/unlocked rods initially.
  • At 12 weeks, unlocked rods showed significantly greater deformity (34.9°) compared to locked rods (25.0°).
  • No implant failures occurred, but aggressive rod contouring resulted in vertebral endplate fractures. Serum nickel levels remained unchanged post-implantation.

Conclusions:

  • Nitinol rods reliably created spinal deformities in an animal model, indicating their potential for future spinal deformity correction applications.
  • Square nitinol rods, due to their reduced stiffness when cooled, show promise for predictable axial plane correction.
  • Further research is needed to optimize rod design and fixation to prevent complications like vertebral fractures.