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Updated: Jun 5, 2026

Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
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Published on: April 23, 2012

Deoxynivalenol and its toxicity.

Pavlina Sobrova1, Vojtech Adam, Anna Vasatkova

  • 1Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic.

Interdisciplinary Toxicology
|January 11, 2011
PubMed
Summary

Deoxynivalenol (DON), a mycotoxin from Fusarium species, contaminates grains and poses health risks to humans and animals through food. This review covers DON toxicities, reproductive effects, and interactions.

Keywords:
Deoxynivalenol (DON)Fusariumgrainmycotoxintoxicity

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Area of Science:

  • Food Science
  • Toxicology
  • Mycology

Background:

  • Deoxynivalenol (DON) is a prevalent mycotoxin produced by Fusarium species, contaminating staple grains like corn and wheat.
  • Human exposure occurs through direct consumption of plant-based foods or indirect consumption of animal products.
  • DON has been identified in a wide array of food products, including cereals, baked goods, and beverages.

Purpose of the Study:

  • To review the toxicological profile of Deoxynivalenol (DON).
  • To summarize the effects of DON on animal and human reproduction.
  • To discuss the antagonistic and synergistic actions of DON with other substances.

Main Methods:

  • Literature review of scientific publications on Deoxynivalenol.
  • Compilation of data on DON occurrence in food commodities.
  • Summary of reported toxicological and reproductive effects.

Main Results:

  • DON exposure can lead to acute symptoms such as nausea, vomiting, diarrhea, and fever.
  • The mycotoxin affects various animal organs and has implications for human health.
  • Information on DON's reproductive toxicity and its interactions is presented.

Conclusions:

  • Deoxynivalenol (DON) represents a significant food safety concern due to its widespread presence and adverse health effects.
  • Understanding DON's toxicity and interactions is crucial for risk assessment and mitigation strategies.
  • Further research into reproductive effects and synergistic actions is warranted.