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Triterpenoids from Psidium guajava with Biocidal Activity.
P Ghosh1, A Mandal, P Chakraborty
1Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling - 734 013, India.
Indian Journal of Pharmaceutical Sciences
|January 11, 2011
Summary
Two triterpenoids, betulinic acid and lupeol, were isolated from Psidium guajava leaves. These compounds show potential antimicrobial and phytotoxic activities, contributing to ethnobotanical research.
Area of Science:
- Phytochemistry
- Pharmacology
- Plant Science
Background:
- Medicinal plants from the Darjeeling and Teri foothills are a source of bioactive compounds.
- Psidium guajava (guava) is traditionally used for various ailments.
Purpose of the Study:
- To isolate and identify triterpenoids from Psidium guajava leaves.
- To evaluate the antimicrobial and phytotoxic potential of the isolated compounds.
Main Methods:
- Phytochemical analysis of Psidium guajava leaf extract.
- Isolation of compounds using chromatographic techniques.
- Structural elucidation using Infrared (IR) and Nuclear Magnetic Resonance (NMR) spectroscopy.
- Assessment of antimicrobial activity against various pathogens.
- Evaluation of phytotoxic effects on plant growth.
Main Results:
- Betulinic acid and lupeol were successfully isolated from the leaf extract.
- The structures of betulinic acid and lupeol were confirmed by spectral data.
- The isolated compounds exhibited notable antimicrobial and phytotoxic activities.
Conclusions:
- Psidium guajava leaf extract contains bioactive triterpenoids, betulinic acid and lupeol.
- These compounds possess promising antimicrobial and phytotoxic properties, warranting further investigation for therapeutic and agricultural applications.
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