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Spectrophotometric Assay of Mefenamic Acid in Tablets Using 1,4-dioxane as Solvent for Extraction.

G Mathai¹, J T Moolayil, K B Jose

¹Department of Chemistry, Sacred Heart College, Thevara, Kochi- 682 013, India.

Indian Journal of Pharmaceutical Sciences

|January 11, 2011

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A new spectrophotometric method accurately quantifies mefenamic acid in tablets. This reliable assay uses 1,4-dioxane and UV-Vis spectroscopy for pharmaceutical analysis.

Area of Science:

Analytical Chemistry
Pharmaceutical Analysis
Spectroscopy

Background:

Mefenamic acid is a widely used nonsteroidal anti-inflammatory drug (NSAID).
Accurate quantification of active pharmaceutical ingredients (APIs) in dosage forms is crucial for quality control.

Purpose of the Study:

To develop and validate a simple spectrophotometric method for assaying mefenamic acid in tablet formulations.
To establish a reliable analytical technique for routine pharmaceutical quality control.

Main Methods:

Dissolving tablet powder in 1,4-dioxane.
Measuring absorbance at 353.2 nm using UV-Vis spectrophotometry.
Determining mefenamic acid concentration via a pre-established calibration curve.

Keywords:

Dioxane mefenamic acid spectrophotometric assay

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Main Results:

The developed spectrophotometric method demonstrated effective quantification of mefenamic acid.
The method was successfully applied to assay six different commercial mefenamic acid tablet products.
The assay provides a straightforward and reproducible approach for mefenamic acid determination.

Conclusions:

A validated spectrophotometric method using 1,4-dioxane is suitable for the quantitative assay of mefenamic acid in tablets.
This method offers a practical tool for pharmaceutical quality assurance and control of mefenamic acid products.