Related Experiment Video
Updated: Jun 5, 2026
In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy
Published on: September 11, 2013
Imaging techniques used for the real-time assessment of angiogenesis in digestive cancers
Abstract:
Angiogenesis has a critical role in primary tumor growth and the development of metastases. Several angiogenesis inhibitors were recently developed, being a very attractive target for digestive tumor therapy. However, individualized therapy should not only be based on the pre-treatment imaging evaluation, but also on sensitive monitoring of microvascular changes during treatment. State-of-the-art imaging techniques have the potential to visualize and characterize angiogenesis, although the technology and methodologies employed are recent and need further validation. The aim of this series of reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers, used for the longitudinal monitoring of the effects of chemo-radiotherapy (including anti-angiogenic therapies), as well as for the precise targeting of drugs through molecular-based drug-delivery systems.
Insights
Monitoring angiogenesis, the growth of new blood vessels, is crucial for digestive tumor treatment. Advanced imaging can track microvascular changes during therapy for personalized cancer care.
Area of Science:
- Oncology
- Medical Imaging
- Biomedical Engineering
Background:
- Angiogenesis is vital for primary tumor growth and metastasis.
- Angiogenesis inhibitors are promising for digestive tumor therapy.
- Individualized treatment requires pre-treatment imaging and sensitive monitoring of microvascular changes.
Discussion:
- State-of-the-art imaging techniques can visualize and characterize angiogenesis.
- Current imaging technologies and methodologies for angiogenesis assessment are novel and require further validation.
- Real-time assessment of angiogenesis is essential for longitudinal monitoring of treatment effects.
Key Insights:
- Digestive tumor therapy benefits from targeting angiogenesis.
- Sensitive monitoring of microvascular changes during treatment is necessary for personalized therapy.
- Advanced imaging holds potential for visualizing and characterizing angiogenesis.
Outlook:
- Further validation of imaging technologies for angiogenesis assessment is needed.
- Future research should focus on real-time assessment of angiogenesis in digestive cancers.
- Molecular-based drug-delivery systems can enable precise drug targeting for enhanced efficacy.
More Related Videos
09:03Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
12:23Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
Published on: August 14, 2012
Related Concept Videos
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...