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Related Experiment Video

Updated: Jun 5, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Microvalve Enabled Digital Microfluidic Systems for High Performance Biochemical and Genetic Analysis.

Erik C Jensen1, Yong Zeng, Jungkyu Kim

  • 1Biophysics Graduate Group, University of California, Berkeley, CA 94720.

JALA (Charlottesville, Va.)
|January 11, 2011
PubMed
Summary

Monolithic membrane valves enable advanced digital microfluidic platforms for precise nanoliter-scale sample manipulation. These systems enhance automation, throughput, and sensitivity in medical diagnostics and research.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Laboratory Automation

Background:

  • Digital microfluidics provides advanced automation for sample processing and assays in diagnostics and research.
  • Monolithic membrane valves are key components for precise control of microfluidic systems.

Purpose of the Study:

  • To develop novel digital microfluidic platforms using monolithic membrane valves for automated sample processing.
  • To enhance throughput, sensitivity, and programmability in microfluidic assays.

Main Methods:

  • Development of a digital microfluidic Automaton with 2D microvalve arrays for combinatorial sample processing.
  • Integration of microfabricated emulsion generator array (MEGA) devices with 3-microvalve pumps for droplet generation.
  • Utilizing a 96-channel MEGA device for high-throughput droplet generation.

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Digital Microfluidics for Automated Proteomic Processing
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Digital Microfluidics for Automated Proteomic Processing

Published on: November 6, 2009

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
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A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments

Published on: August 6, 2013

Related Experiment Videos

Last Updated: Jun 5, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Digital Microfluidics for Automated Proteomic Processing
10:55

Digital Microfluidics for Automated Proteomic Processing

Published on: November 6, 2009

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
12:21

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments

Published on: August 6, 2013

Main Results:

  • The digital microfluidic Automaton enables programmable, rapid integration of diverse assay protocols.
  • MEGA devices generate uniform nanoliter droplets for encapsulating microbeads and cells.
  • A 96-channel MEGA device achieves over 3.4 million nanoliter droplets per hour for rare mutation detection.

Conclusions:

  • Novel digital microfluidic platforms significantly improve automated sample processing and analysis.
  • These platforms offer enhanced throughput, sensitivity, and programmability for research and diagnostics.
  • Monolithic membrane valve technology is crucial for advancing microfluidic automation.