Solid-State Forms of β-Resorcylic Acid: How Exhaustive Should a Polymorph Screen Be?

Area of Science:

• Solid-state chemistry
• Crystallography
• Materials science

Background:

• Beta-resorcylic acid is a compound with potential applications.
• Understanding its solid-state forms is crucial for its use.
• Polymorphism influences material properties.

Purpose of the Study:

• To identify and characterize new solid-state forms of beta-resorcylic acid.
• To investigate phase transformations between different forms.
• To provide a comprehensive understanding of beta-resorcylic acid's solid-state behavior.

Main Methods:

• Extensive experimental screening (e.g., crystallization techniques).
• Computational studies (e.g., theoretical modeling).
• Solid-state characterization techniques (e.g., X-ray diffraction, thermal analysis).

Main Results:

• Seven novel solid-state forms of beta-resorcylic acid were identified.
• A reversible phase transformation was observed between the known stable polymorph II° and a new high-temperature form (form I).
• The new high-temperature form is likely kinetically stable and disordered.

Conclusions:

• The study elucidates the complex solid-state landscape of beta-resorcylic acid.
• New forms and a reversible phase transition were characterized.
• This work offers a consistent understanding of beta-resorcylic acid's solid-state properties.