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Related Concept Videos

Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

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Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
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Published on: January 29, 2020

An interspecies computational study on limb lengthening.

E Reina-Romo1, M J Gómez-Benito, J M García-Aznar

  • 1Department of Mechanical Engineering, University of Seville, 41092-Seville, Spain. erreina@us.es

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
|January 12, 2011
PubMed
Summary
This summary is machine-generated.

This study numerically compares tissue distribution during distraction osteogenesis across species. The findings align with experimental results, showing the model

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Published on: December 7, 2011

Area of Science:

  • Biomechanical engineering
  • Orthopedic surgery
  • Regenerative medicine

Background:

  • Distraction osteogenesis (DO) is a surgical method for bone regeneration.
  • Mechanical models can predict outcomes in DO, including pre-traction stresses.
  • Understanding interspecies variations in DO is crucial for clinical application.

Purpose of the Study:

  • To numerically compare spatial and temporal tissue distribution patterns during distraction osteogenesis.
  • To evaluate a mechanical model's ability to predict experimental results across different species (sheep, rabbit) and humans.
  • To analyze tissue distribution and reaction forces as indicators of healing patterns in DO.

Main Methods:

  • Utilized a previously proposed mechanical-based model incorporating pre-traction stresses.
  • Performed numerical simulations comparing sheep, rabbit, and human distraction osteogenesis.
  • Selected interspecies differential characteristics (size, distraction protocol, rate) based on experimental data.
  • Analyzed tissue distributions and reaction forces as healing indicators.

Main Results:

  • Numerical results demonstrated agreement with experimental findings for tissue distribution and reaction forces.
  • The model successfully predicted healing patterns in both animal models and human subjects.
  • Identified interspecies variations in tissue distribution and reaction forces during DO.

Conclusions:

  • The mechanical model can qualitatively predict distraction osteogenesis healing patterns across species.
  • The model shows potential for understanding the biomechanical influences on bone regeneration in DO.
  • Numerical simulations provide valuable insights into optimizing DO protocols.