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Photoreactions of furocoumarins with biomolecules
1Département de Recherche Fondamentale, Centre d'Etudes Nucléaires de Grenoble, France.
Abstract:
Recent aspects of the photoreactions of linear and angular furocoumarins with DNA and related compounds, including [2 + 2] cycloaddition to pyrimidine bases, covalent attachment to the osidic moiety of adenine nucleosides and photodynamic effects, are surveyed. Reactions of photoexcited furocoumarins with proteins and unsaturated lipids and the possible biological roles of the resulting adducts are also presented and discussed.