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Heparin and prednisone-associated priapism: two case reports
Andrologia
|January 12, 2011
Summary
Priapism, a prolonged erection, can be triggered by heparin and prednisone. This report details two cases, highlighting potential drug-induced priapism and successful treatment outcomes.
Area of Science:
- Urology
- Pharmacology
- Hematology
Background:
- Priapism is defined as a prolonged penile erection unrelated to sexual stimulation.
- Low-flow priapism is commonly linked to conditions like sickle cell disease, hematologic disorders, certain medications, and idiopathic causes.
Observation:
- This report describes two patients who experienced priapism 2-4 hours after receiving oral prednisone and intravenous heparin.
- The observed priapism was characterized as low-flow (ischemic).
Findings:
- The study presents two cases of prolonged low-flow priapism potentially induced by a combination of heparin and prednisone.
- Successful treatment interventions were administered to both patients.
Implications:
- This case series suggests a potential link between heparin and prednisone use and the development of drug-induced priapism.
- Further research is warranted to elucidate the exact mechanism underlying this adverse drug reaction.
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