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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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Related Experiment Video

Updated: Jun 5, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Using primary care prescribing databases for pharmacovigilance.

Isa Naina Mohamed1, Peter J Helms, Colin R Simpson

  • 1Division of Applied Health Sciences, Institute of Child Health, University of Aberdeen, Aberdeen, UK.

British Journal of Clinical Pharmacology
|January 12, 2011
PubMed
Summary
This summary is machine-generated.

Adverse drug reactions (ADRs) are a significant burden. This study developed a system to identify ADRs by monitoring patient drug discontinuation, finding it effective for detecting ADRs in primary care.

More Related Videos

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Related Experiment Videos

Last Updated: Jun 5, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Area of Science:

  • Pharmacovigilance
  • Health Informatics
  • Primary Care Medicine

Background:

  • Adverse drug reactions (ADRs) cause substantial morbidity and healthcare costs in the UK, contributing to over 6.5% of hospital admissions.
  • Identifying the specific reasons for patients discontinuing medication is crucial for effective ADR monitoring and patient safety.

Purpose of the Study:

  • To develop and evaluate a system for monitoring adverse drug reactions (ADRs) by analyzing patient discontinuation of drug therapy within six months of initial prescription.
  • To assess the feasibility of using primary care prescribing databases for identifying ADRs.

Main Methods:

  • A cohort of patients prescribed amlodipine between March 2004 and February 2007 who discontinued within six months was identified using the Practice Team Information (PTI) database.
  • Reasons for discontinuation were assessed via electronic database searches (Readcodes, keywords) and direct review of primary care records.

Main Results:

  • The PTI database identified 995 patients discontinuing amlodipine within six months; 19.4% had a recorded ADR.
  • Direct review of records from participating practices revealed that 98% of discontinuations were due to an ADR or adverse drug event.

Conclusions:

  • Primary care prescribing databases are a valuable tool for identifying the frequency and nature of ADRs.
  • Medication discontinuation serves as an effective indicator for identifying ADR-enriched patient populations.