Contribution of skin trauma to infantile skin hemangioma

Infantile skin hemangiomas (ISHs), the most common tumor of infancy, is a kind of benign vascular tumors that are characterized by their dramatic growth after birth, by diffusing proliferation of immature endothelial cells, followed by a spontaneous involution phase. Existing therapeutic approaches have limited success and significant adverse effects of some treatment modalities due to the limitation of their use. Better understanding of the pathogenesis of ISH will enables the development of better therapeutic strategies. The mechanisms for the development of ISHs are not completely understood and their pathogenesis is just now being elucidated. We hypothesize that skin trauma-induced hypoxia triggers neovascularization, which encompasses both angiogenesis and vasculogenesis, leading to the formation of ISHs. Assuming the hypothesis correct, the paper is aimed at come up with a prophylaxis and therapy that prevent infants from both intrauterine and extrauterine trauma, and inhibit excessive neovascularization by some medicine to prevent the ISHs formation.