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Mitotane has a strong and a durable inducing effect on CYP3A4 activity

Nielka P van Erp1, Henk-Jan Guchelaar, Bart A Ploeger

  • 1Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, PO Box 9600, Postal zone L0-P, 2300 RC Leiden, The Netherlands. p.h.van_erp@lumc.nl

European Journal of Endocrinology
|January 12, 2011
PubMed
Summary

Mitotane significantly induces CYP3A4 activity, leading to reduced exposure of drugs like midazolam and sunitinib. This effect is long-lasting and has clinical implications for patients on multiple medications.

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